[print-me] Dr.Ikram Mohammed Eltayeb Elsiddig, Associate Professor at the Faculty of Pharmacy published paper in the International Journal of Current Research. The paper, which is entitled “Phytochemical study and anti-hyperglycemic effects of allium sativum bulbs growing in Sudan” is a joint effort with Yacouba Amina Djamila and 2Amna El Hassan Hama of the Department of Pharmacognosy, Faculty of Pharmacy, University of Medical Sciences and Technology and of the Department of Pharmacology, and Amna El Hassan Hamad Medicinal and Aromatic Plants Research Institute, Khartoum.
“Heart disease remains a major killer with the World Health Organization estimating it will be second to cancers by 2030. It’s clear we need new treatment options,” said Mazin Sirry of the Department of Biomedical Engineering, University of Medical Sciences and Technology, Khartoum, Sudan. Sirry was presenting an overview of the research project he is conducting while at STIAS in which he will use computer modelling to investigate the mechanics of biomaterial injections in hearts damaged by heart attack.
Myocardial infarction, or a heart attack, is a major cause of death globally. The South African Heart and Stroke Foundation estimates that cardiovascular diseases as a whole (including heart disease and strokes) kill 17 million people annually globally and are responsible for almost 1 in 6 deaths in South Africa.
“In ischaemic heart disease there is usually a blockage in the coronary artery – the heart cells without access to blood die off causing irreversible damage,” said Sirry. “This causes loss of contraction in the muscles affecting the pumping action of the heart and causing a heart attack or myocardial infarction. Heart cells do not regenerate so the damaged cells are not replaced thus causing long-term heart failure.”
Current treatments include drug therapy which aims to prevent clotting and reduce heart stress; interventions like the placement of a balloon and stent which dilates the occluded artery and restores blood flow; bypass surgery to replace the damaged artery; the use of mechanical support devices including placing a mesh around the heart to assist in pumping the blood; or heart transplantation.
“Each case has its own needs,” said Sirry, “and you need to choose the best tools.”
“However, for transplantation there is generally a shortage of donors, high cost and risk of transplant failure,” he continued. “It also requires specialised clinics that are not necessarily available on a large scale in low-income settings.”
It’s therefore clear that newer therapies are needed and one option is therapies based on cell-delivery approaches.
“This means injecting immature cells into the affected region to replace the damaged cells. The injection usually includes biomaterials along with the cells and has shown good results in reducing the size of the area damaged by the infarction.”
But the research in this area was not without debate because it wasn’t clear if the results were due to the cells or if the biomaterials alone had an impact.
“A 2006 study demonstrated that cardiac function might potentially be improved just by increasing the thickness of the ventricle wall by the use of biomaterials,” said Sirry. “In 2009 a research group at the University of Cape Town developed a synthetic polyethylene glycol hydrogel which on its own showed good results in preventing the adverse ventricular remodelling.”
“These and other studies showed that cell and biomaterial injection therapy is a new and promising treatment for myocardial infarction. However, it has not yet been fully optimised.”
It became clear that an increased understanding of the mechanical aspects of the heart was needed including understanding the alterations induced by the biomaterial injection at a microscopic level. This is where computational modelling was found to be extremely useful.
Sirry’s research therefore uses computer models to help to understand the underlying mechanical mechanisms and to predict the changes that occur when the gel is injected.
“This gives us important information on the volume, the geometry and shape of the gel within the tissues, the underlying patterns formed and, hopefully also information on the optimal location and timing of the gel injection. We hope to attain a realistic configuration of what happens to the gel once it is injected and how this might optimise treatment.”
“The aim is to understand the micromechanics of a biomaterial injected into an infarcted heart using computer modelling.”
“All previous studies have been at the level of the organ now there is a need to go to the microscopic level to obtain a more detailed model of how the gel configures itself within the heart structure. An infarct leads to huge microscopic changes, you therefore can only understand the positive outcomes of the use of the gels by looking at the microscopic level. Then you translate that information back from the microscopic to the organ level,” continued Sirry.
He hopes the project will provide a platform for understanding and addressing the microscopic aspects of treatment and, also importantly, will give information on what happens if you go back to injecting cells not just biomaterials. The ultimate goal is to eventually regenerate the damaged heart cells.
But Sirry was quick to emphasise that all of these studies are at a preclinical level and that it will be a long time before they are translated into generally available treatments therefore in the interim the best is to avoid the occurrence of heart attack as much as possible through healthy lifestyle choices.
Expanding the field of biomechanical engineering
Sirry also spoke about his efforts to establish a biomechanics educational and research laboratory at his home institute in Sudan.
“To date, there has been low interest or understanding of biomechanics generally in the Sudan,” he said. “People educated and trained in this field often don’t return to the country.”
“There is more of an emphasis on training around medical electronics and imaging but no actual biomechanics,” he added.
Sirry therefore aims to promote the field by contributing to research, education and training, developing capacity and increasing awareness of biomechanical engineering in the country as a whole and particularly among the medical profession.
His efforts thus far have resulted in increased interest and enrolment in biomechanics research as well as a first attempt to establish a simple educational motion-tracking laboratory which can be used to characterise human movement.
Michelle Galloway: Part-time media officer at STIAS
Photograph: Christoff Pauw
Four research papers from UMST Faculty of Engineering were recently presented at the International Conference on Computer, Control, Electrical and Electronics Engineering (ICCCEEE18) held at Corinthia Hotel, Khartoum, during 12-14 August 2018. All four papers were based on recent graduation projects of final year undergraduate students from Electonics and Biomedical Engineering departments. The conference, organized by University of Gezira, was co-sponsored by Institute of Electrical and Electronics Engineers (IEEE), IEEE Region 8 (Europe, Middle East and Africa) and IEEE Sudan subsection.
Details of published papers:
Title: “Enhanced Smart Water Meter Efficiency Based On Mounting Position Selection and Extended Battery Life Time”
Authors: Khaleel A. Mohammed, Mark G. Munier, Priscilla P. William, Sami A. Nagar, Ali M. A. Ibrahim
Department: Electronics Engineering
Title: “Designing a Verbal Deaf Talker System Using Mouth Gestures”
Authors: Amro M. Hassan, Ashraf H. Bushra, Osama A. Hamed, Ahmed Labeeb
Department: Electronics Engineering
Title: “Mathematical Model Implementation of Network Decision Algorithms in Heterogeneous Network Based on QoS Parameters”
Authors: Aridegbe A. A. Ipaye, Israa I. O. Ahmed, Dimitrios N. G. Mitropoulos, Ali M. A. Ibrahim, Sami A. Nagar
Department: Electronics Engineering
Title: “Design of Noninvasive Continuous Glucose Monitoring System”
Authors: Ragda Mamoun, Mohammed El Hadi, Emtithal Ahmed, Omer Adam
Department: Biomedical Engineering
Faculty of Economics, Social & Environmental Studies (FESES) research project oral examinations for the final year students (batch 5) was held on 8, 9 and 10th of July 2018. A total of 32 students from four departments; applied economics (6 students), environmental studies (11 students), international relations (14 students), and sociology (1 students) defended their research projects, which were assessed by the external examiners and faculty staff. Overall, the students demonstrated strong knowledge and excellent research abilities. In addition, the external examiners expressed their appreciation for the efforts made by students and faculty members.
In their sustained efforts to keep abreast with technological developments and academic issues and concerns, Abeer Mohammed Kheir Osman, Web Administrator /Head of Computer Labs Unit, UMST and Eng.Ahmed Abobaker, Web Administrator at the Computer Center, attended on Tuesday the 26th of June at the Conference Hall of the Ministry of Higher Education and Scientific Research, a Lecture on Global University Rankings and the Opportunities for Sudanese Universities.
The lecture was presented by Dr. Nimir Elbashir, Professor of Chemical Engineering & Petroleum Engineering at Texas A&M University and Director of Gas & Fuels Research Center in Qatar. In his lecture Professor Elbashir lecture demonstrated that the quality in university education is measured by the academic institution commitment to excellence in teaching, knowledge transfer, research, and global outlook. He emphasized that he teaching excellence depends primarily on the ability of the universities to facilitate ideal learning environment and to develop effective tools to measure their professors’ role in promoting excellent teaching methods and styles.
Professor Elbashir promised to present two further presentations that will highlight the path to achieving excellence in teaching research and service in academic institutions that will hopefully result in enhancing the ranking of the Sudanese universities.
Quality in university education is measured by the academic institution commitment to excellence in teaching, knowledge transfer, research, and global outlook. The teaching excellence depends primarily on the ability of the university to facilitate ideal learning environment and to develop effective tools to measure their professors’ role in promoting excellent teaching methods/styles, provide the needed mentorship for their students, and measure their preparedness and performance in real life jobs. On the other hand, research excellence is measured by the reputation of the academic institution regarding scientific papers, patents, research income in dollars as well as the number of graduate students (Ph.D. and master) and their impact. Creating globally recognized university require building robust research structure and developing strategy of research dissemination (journal papers and books publications, participation in global conferences, etc.) This presentation will highlight the experience of regional universities in this path. A series of two presentations will highlight the path to achieving excellence in teaching research and service in academic institutions that will result in enhancing the ranking of the Sudanese universities.
Dr. Nimir O. Elbashir
Professor of Chemical Engineering & Petroleum Engineering
Director of Texas A&M University Gas & Fuels Research Center, the Largest University Research Energy Research Center
Dr. Elbashir is a Professor of Chemical Engineering & Petroleum Engineering at Texas A&M University at Qatar and he is the Director of Texas A&M’s Gas and Fuels Research Center; a major research center that involves 31 faculty members from both the College Station and Qatar campuses. Dr. Elbashir is also the Director of the ORYX GTL Gas-to-Liquid Technology Excellence Program. He has extensive research and teaching experience from four different countries around the world. The focus of his research activities is the design of advanced reactors, catalysts and conversion processes for natural gas, coal and CO2 to ultra-clean fuels and value added chemicals. He has established several unique global research collaboration models between academia and industry with research funds exceeding $13m dollars. He holds several US and European patents and a large number of scientific publications in form of books, peer reviewed journals, conference papers, technical industry reports as well as invited and conference presentations. He is the recipient of several prestigious awards including but not limited to: 2017th Texas A&M University Faculty Excellence Award; 2016th Texas TEES Genesis Engineering Research Award; 2012th Qatar Foundation Best Energy & Environment Research Team; 2015th Texas A&M Qatar Dean Leadership Award; 2016th ORYX GTL Recognition Excellence Program: 2013th Shell Recognition of Excellence in GTL Aviation Fuels; 2007th BASF Corp. Excellence Research in Environmental Catalysis, the Gordon Research Conferences.
Will provide a video of the lecture soon..
The Faculty of Medicine would like to share with those who might be interested a number of Research Abstracts submitted by the finalist students at the Faculty. Read more…
UMST Staff Mohammed kamal, Represents Sudan at Science and Technology Forum in DR Congo-Kinshasa Read more…