Dr Alawia Imam’s Pharmaceutical Development Center


Aims & Objectives

The Development Center was established with the aim to:

– Create links and synergies between academicians, pharmaceutical and chemical industries and governmental pharmaceutical sectors.
– Conduct research on, development and implementation of new active pharmaceutical ingredient (API) formulations that warrant simplicity, efficacy and safety at reasonable cost.
– Develop methods that stabilise drugs and drug products under the environmental conditions of Sudan.
– Research the exploitation of local natural resources to discover potential APIs or other pharmaceutical substances.

– Design new analytical techniques for the accurate, rapid and non-destructive evaluation of pharmaceutical products.
– Develop quality assurance and quality control programmes for evaluation of physical and chemical properties, stability, bioavailability and efficacy of new batches and finished drug formulations as well as the coeducation of bioequivalence studies for generic drugs.
– Detect, identify and quantise of toxins and toxic substances in biological fluids and unknown substances in counterfeit medicines and unauthorised products.

– Develop research in the detection and estimation of pollutants in air, water and food/feed commodities.
– Create training programs in instrumental analysis in all applied science fields and in research leading to the award of Diplomas, Master and PhD degrees.
– Promote educational research and training capabilities of undergraduates, graduates, staff members and other relevant parties.

General Director of Dr Alawia Imam’s Pharmaceutical Development Center, Professor Dhia Eldin Abd Elmagied Elhag

Alawia Imam Pharmaceutical Research and Development Institute is a multi-disciplinary and multi-functional research centre of learning, educational and training institute. It has emerged from the objective of UMST strategic thinking to develop a solid plan to guide the university adopt operational effectiveness which embodies performing similar academic activities better than rivals perform them.

Accordingly, the establishment of this institute adds an increment for UMST to sustain its nationally and internationally distinguished academic position via entailing different methodologies and different ways that provide products of highly competitive caliber of young, scientifically oriented professionals and researchers. It also provides excellent analytical services to the community for all its varied sectors. Alawia Imam Pharmaceutical Research and Development Institute comprises at the present, Five Units (outlined in the section below).

The Units are annexed with a number of analytical laboratories available for use by all Units. The laboratories are equipped with sophisticated high tech instruments that are aimed beside research and training programs to provide analytical services, shown elsewhere in this report. Internationally approved official methods of qualitative and quantitative analytical methods of extraction, separation, identification and estimation are available and adopted as reference documents.

Targeted Groups and Centres

  • Pharmaceutical and Chemical Industries Quality Control laboratories and personnel.
  • Hospitals and Ministry of Health laboratories
  • Pharmaceutical and Chemical Industries Researchers.
  • Government Departments, private sector companies and individuals.
  • Private business, factories and companies groups
  • Undergraduate and postgraduate research students
  • Food and feed processing groups and assurance food safety.
  • Environment and occupational health groups.

Mission

The Institute is heading towards being a leading and most valued partner of the pharmaceutical and chemical industry for research and development of new drug and recognized globally for delivering high standard of services and competence that result in excellent performance and a trusted partner whose hallmarks are qualified scientists, high quality data, and a proven track record of integrating and streamlining development processes. Most importantly, based on its well equipped laboratories and its quailed technical personnel and long experienced professors the Institute is heading towards being a locally certified laboratory, then regionally and finally internationally Accredited Laboratory.

Technical Training Programs

The following, short period, laboratory training programs are offered for undergraduate, postgraduate students, technicians, quality control personnel and researchers. These programs comprise the operation, calibration, use and interpretation of the results obtained from instrumental analysis utilizing the following instruments: Chromatographic analysis (HPLC/MS; LC/MS) and spectroscopic analysis (UV/Vis; AA and FTIR). The programs shown below will commence within few weeks:

  • Training in the operation and uses of HPLC/MS and LC/MS chromatographic instruments.
  • Training in the operation and uses of GC/MS chromatographic instruments.
  • Training in the operation and uses of the UV/Vis spectrophotometer.
  • Training in the operation and uses of the FT/IR spectrometer.
  • Training in the operation and uses of the Atomic Absorption spectrophotometer.

Analytical Services

  • Chemical analysis of drugs.
  • Insecticide and herbicides residue analysis.
  • Mineralogical and soil analysis.
  • Environmentalists groups (occupational hygiene).
  • Analysis of toxic and carcinogenic minerals pollutants in water, soil and air.
  • Analysis of herbal preparations for safety and efficacy.
  • Oil content of seeds and fatty acid composition of vegetable oils.
  • Chemical Composition of Essential oils (volatile oils).
  • Analysis and separation of components of crude extracts.
  • Anti-fungal and anti-bacterial activity properties of essential oils.
  • Analysis of toxic and carcinogenic additives of Creams, ointments and cosmetics.
  • Analysis nutritive values of food commodities.
  • Analysis of additives of drinks and food commodities.
  • Analysis of milk and milk products.
  • Analysis of mycotoxins in food and feeds.
  • Analysis of precious minerals (gold, silver, copper etc) in samples of and rocks and sands.
  • Analysis of toxic minerals in food, feed and raw materials
  • Pesticides residue analysis in agricultural commodities (fruits, vegetables etc)
  • Quality Characteristics Analysis of chemical and pharmaceutical industries raw materials.
  • Diagnostic and clinical tests in blood, urine and plasma.

Units

Analytical Services Unit (ASU)

The analytical services unit provides chemical and instrumental analytical services for samples delivered by research students, food and agricultural commodities from companies and food industry, raw materials for pharmaceutical and chemical industries. See the types of analytical services the Institute can provide elsewhere in this report.

Pharmacological and Toxicological Research Unit (PTRU)

The PTRU works on biological research in vitro and in vivo pharmacology and biochemistry. The laboratory facilities for this unit were identified and will be available in the near future.

Pharmaceutical technology Unit(PHTU)

The unit will house research groups working on drug dosage forms development and production. The facilities needed for PHTU will be organized in the following adjoining areas:

  • Non-GMP area: to research on pharmaceutical technology (based on quality by design and process analytical technology principles of pharmaceutical development and production). Pharmaceutical technology comprises process analysis, technological drug development and production. Processes include granulation, tablet pressing, homogenization etc.
  • GMP area: pharmaceutical technology areas with the capability of implementing good manufacturing practice (GMP) for producing drug dosage forms for clinical trials. The GMP area can be run by/with external partners and its placement with the non-GMP research area will generate a synergistic effect.

Pharmaceutical analysis and quality control Unit (PHA & OCU)

The PHA & OCU will house researchers conducting interdisciplinary research in analytical chemistry in relation to bioorganic and inorganic chemistry, drug metabolism, and toxicology, environmental chemistry and physical chemistry.

This broad-ranging unit will have a well equipped laboratory.

Pharmaceutical analysis and quality control Unit (PTRU)

The PTRU works on biological research, in vitro and in vivo pharmacology and biochemistry. The research needs a classified laboratory with all necessary facilities and a small, specialised animal facility to house small laboratory animals together with a full-time animal caretaker.

Drug discovery and design Unit(DDDU)

DDDU comprises a new structure with interdisciplinary cooperation between medicinal chemises, natural products chemises and pharmacologists (for assay development and screening). The Unit’s laboratories shall be provided with the necessary instruments.

Equipment

Atomic Absorption Spectrophotometer [A.A.S]Atomic Absorption Spectrophotometer [A.A.S]

  • Analysis of toxic mineral in rocks, soils, food/feed, cosmetics and water.
  • Analysis of body fluid metals.
  • Analysis of minerals and precious metals in rocks and soils.
  • Analysis of cations in water, foods/feed and agriculture commodities.
  • Analysis of metals in chemical complexes.
  • Analysis of trace toxic minerals in blood samples.
  • Analysis of trace toxic minerals in food and feed commodities.

Gas Chromatography Mass Spectrometer [GC-MS]Gas Chromatography Mass Spectrometer [GC-MS] (2)

  • Analysis of volatile organic compounds in chemical reaction products.
  • Analysis of essential oils of plant materials, perfumes cosmetic and in furrows.
  • Analysis of fatty acids identification and composition in seedoils, food and feed.
  • Analysis of residual solvents in pharmaceutical products.
  • Analysis of volatile pesticides in agriculture commodities.
  • Analysis of residual solvents in drugs.
  • Analysis of residual drubs in blood.
  • Analysis of food additives and contaminants

High Performance Liquid Chromatography [HPLC]High Performance Liquid Chromatography [HPLC]

  • Qualitative and quantities analysis of drugs and pharmaceuticals.
  • Analysis related to Bioequivalence studies.
  • Analysis of non-volatile pesticides in food and feed commodities.
  • Analysis of mycotoxins in food and feed.
  • Analysis of cyano toxins in drinking water.
  • Analysis of additives in drinks, food and feed products.
  • Analysis of fatty acids composition of seed oils.
  • Analysis of micro ingredients hormones, vitamins, phytosterols and tocopherols and glucosinulates in agricultural products and commodities.
  • Analysis of residual solvents in drugs.
  • Analysis of residual drubs in blood.
  • Analysis of food additives and contaminants.
  • Analysis of the components of natural products in plant extracts.
  • Analysis of pharmaceutical raw materials and pharmaceutical products.

Ultra – Violet /Visible (UV-Vis) SpectrophotometerUltraVioletVisibleUV-Vis

  • Quantities analysis of active ingredients of pharmaceutical products.
  • Qualitative and quantities analysis of synthetic organic compounds and pharmaceuticals.
  • Development of spectrophotometric techniques in pharmaceuticals analysis.
  • Spectrophotometric applications in pharmaceutical and chemical research.
  • Determination of the concentration levels of compounds in solution including pollutants in water.
  • Analysis of residual solvents in drugs.
  • Analysis of residual drubs in blood.
  • Analysis of food additives and contaminants

Technical Training Programmes

Short laboratory training programmes are offered for undergraduate and graduate students, technicians, quality control personnel and researchers. These comprise of the operation, calibration, use and interpretation of the results obtained from instrumental analysis utilising: Chromatographic analysis (HPLC/MS; LC/MS) and spectroscopic analysis (UV/Vis; AA and FTIR).

  • Training in the operation and uses of HPLC/MS and LC/MS chromatographic instruments.
  • Training in the operation and uses of GC/MS chromatographic instruments.
  • Training in the operation and uses of the UV/Vis spectrophotometer.
  • Training in the operation and uses of the FT/IR spectrometer.
  • Training in the operation and uses of the Atomic Absorption spectrophotometer.

The Diploma programme in Spectroscopic Methods of Analysis is composed of the following courses: Programmes